No longer far away! The "Quantum Era" has arrived, six cases reveal the future of science and technology wind direction ---

 

Quantum computers work very differently from conventional computers, and they hold great potential for solving key problems that seem unsolvable in classical computers. But the question is, in what practical scenarios can we realize this leap towards what has been hailed as "quantum superiority"?

 

In 2023, a study and analysis by the Association for Computing Machinery (ACM) made the case that the oft-cited use cases that are expected to be accelerated by quantum computing may not realize the expected quantum advantage without a fundamental revolution in algorithms.

 

While the latest findings pour cold water on the hype in the field of quantum computing, there is no need to dismiss the technology's potential prematurely.

 

On March 4, 2024, Google and XPrize announced that they will offer $5 million in prizes to innovators who come up with promising use cases for quantum computers. Ryan Babbush, Google's head of quantum algorithms, responded by saying that this doesn't mean there is a lack of practical application scenarios. He noted, "We are certain that these devices will have a significant impact in some areas."

 

 
Matthias Troyer, vice president of Microsoft Quantum and member of the Xprize competition advisory board, elaborates, "A quantum computer is more like a gas pedal for specific purposes. It can have a significant impact on those particular problems where quantum mechanics can come into play."
 

"Setting off" for the Quantum Era

 

The problems that quantum computers excel at solving stem from their unique historical roots.

 

In 1981, physics giant Richard Feynman introduced the concept of quantum computers, designed to simulate the infinite complexity of the quantum world.

 

 
Link to paper:
https://s2.smu.edu/~mitch/class/5395/papers/feynman-quantum-1981.pdf
 

Since then, scientists have developed a series of ingenious algorithms that enable quantum computers to play a role in non-quantum areas, such as searching databases and cracking codes. For database searches, however, quantum computers may not be able to realize substantial speed advantages in the foreseeable future. Similarly, new types of machines for threatening Internet security appear to be a controversial development.

 

But the latest research points to the potential of quantum computers to simulate quantum phenomena of interest to several industries, possibly sooner than the progress they have made in other applications.

 

 

"The commercial impact of problem solving in quantum systems is mainly seen in the chemical, materials science and pharmaceutical industries." Matthias Troi adds. These are key industry sectors. "From the Stone Age, Bronze Age, Iron Age, Iron and Steel Age to the Silicon Age, we are defining the course of history through material innovation."

 

On the road to a potential new quantum era, here are a few key examples of the empirical quantum advantages that quantum computing researchers expect these devices to demonstrate over the next decade.

 

Troy hopes that the $5 million reward prize will inspire the scientific community to find more ways to apply quantum algorithms to real-world problems. "The goal of this prize is to attract more quantum scientists to focus not just on developing quantum algorithms and theories, but to think about questions like: in what areas are quantum algorithms useful? How can we use quantum computers to solve the major challenges facing the world?"

 

Six application cases

 

1)Breakthroughs in drug metabolism research
 

In a paper in Proceedings of the National Academy of Sciences (PNAS) 2022, the drug company Boehringer Ingelheim, Columbia University, Google Quantum Artificial Intelligence, and QSimulate jointly explore the enzyme cytochrome P450.

 

This enzyme plays a key role in human drug metabolism and is involved in the metabolism of about 70% of drugs. The study found that quantum computers can simulate its oxidation process faster and more accurately than traditional methods, which is significant for drug development.

 

Left: Examples of electronic orbitals (red and blue) of CYP enzymes. More than 60 such orbitals are required to model the CYP system. Right: comparison of the actual running time (CPU) (blue) of various classical techniques with the assumed running time (QPU) (green) of the quantum algorithm. The lower slope of the quantum algorithm suggests that its asymptotic scaling is superior to the classical approach. In about 20-30 orbits, we can see the crossover point where the quantum algorithm is more efficient than the classical approach
 
Link to paper:
https://www.pnas.org/doi/10.1073/pnas.2203533119
 
In a blog post, the researchers wrote: "We found that to correctly parse the chemical reactions in this system, a quantum computer would be needed to provide a higher level of precision, so a quantum computer would not only be better, it would be necessary."
 
2) New strategies for carbon dioxide sequestration
 
In the quest to reduce atmospheric CO2 levels, scientists are exploring ways to convert CO2 into compounds that can be stored for long periods of time. While there are cost and energy efficiency issues with existing technologies, several recent studies have shown that quantum computers are expected to more accurately simulate the reaction of CO2 with catalysts, offering hope for finding more efficient sequestration methods.
 

 
 
Link to paper:
https://journals.aps.org/prresearch/abstract/10.1103/PhysRevResearch.3.033055
 

Application of quantum computing methods to carbon dioxide capture on metal-organic frameworks
 
Link to paper:
https://link.springer.com/content/pdf/10.1140/epjqt/s40507-022-00155-w.pdf?pdf=button
 

 
Link to paper:
https://pubs.aip.org/avs/aqs/article/5/1/013801/2879052/Description-of-reaction-and-vibrational-energetics
 
If these achievements and expected developments are true, scientists will be able to estimate the efficiency of various sequestration candidates more effectively.
 
3) Innovation in Agricultural Fertilization
 

While the traditional method of ammonia production-the Haber-Bosch process-requires high-temperature and high-pressure environments, a team of researchers from Microsoft Research and ETH Zurich is exploring a more environmentally friendly alternative. They are considering the use of nitrogen-fixing enzymes to produce ammonia at room temperature and pressure, which could have revolutionary implications for global food security.

 

The researchers found that classical methods cannot accurately model this reaction, but that classical and quantum computers can work in tandem. Troy, who worked on the study, said, "For example, if you could find the chemical process of nitrogen fixation on a small scale on a farm in a village, that would have a huge impact on food security."

 

 
Link to paper:
https://www.pnas.org/doi/full/10.1073/pnas.1619152114
 
4) Seeking alternative battery cathode materials
 

Due to the environmental and safety concerns associated with cobalt mining, scientists are looking for alternatives, such as nickel. A study conducted by BASF, Google Quantum Artificial Intelligence, Macquarie University in Sydney and QSimulate worked to simulate a nickel-based cathode - lithium nickel oxide - on a quantum computer to explore the possibility of producing a stable material.

 

Pure lithium nickel oxide is not stable during production and little is known about its basic structure, the researchers said. If the ground state of this material can be better modeled, it may be possible to find ways to make a stable version. In a blog post, the authors wrote: "The quantum computational requirements needed to adequately model this problem are beyond the capabilities of the first error-correcting quantum computers, but we expect this number to decrease with future algorithmic improvements."

 

Four candidate structures for LNO. In the paper, the scientists consider the resources needed to compare the energies of these structures in order to find the ground state of LNO
 
Link to paper:
https://journals.aps.org/prxquantum/abstract/10.1103/PRXQuantum.4.040303
 
5) Quantum computational simulation of fusion reaction energy
 

In 2022, the National Ignition Facility (NIF) in the United States made headlines when it performed the first inertial fusion reaction, producing more energy than was directly put into it. In an inertial fusion reaction, a tritium-deuterium mixture is heated by a laser until it forms a plasma and collapses in on itself, triggering a fusion reaction. Babush, who worked on the study, explained that this plasma is extremely difficult to model.

 

He said, "Hundreds of millions, if not billions, of CPU hours have been spent by the Department of Energy calculating just one quantity."

 

In a preprint, Babush and his collaborators outline an algorithm with which a quantum computer could model the full complexity of the reaction. This, like battery cathode research, would require more quantum bits than are currently available, but the authors believe that future hardware and algorithmic improvements may close the gap.

 

 
Link to paper:
https://arxiv.org/abs/2308.12352v1
 
6) Improvements in Quantum Sensor
 

Unlike quantum computers, quantum sensors are already having an impact on the real world.

These sensors measure magnetic fields more accurately than any other technology and are currently being used in brain scans, gravity measurements for mapping geological activity, and more. The output of quantum sensors is quantum data, but currently reads out classical data, the traditional 1s and 0s, ignoring some of the full quantum complexity.

 

In 2022, a study conducted in collaboration with Google, Caltech, Harvard, UC Berkeley, and Microsoft showed that if the output of a quantum sensor is imported into a quantum computer, a clever algorithm can be used to learn relevant properties with exponentially fewer copies of the sensor's data, resulting in faster readouts.

 

They demonstrated their quantum algorithm on an analog sensor, showing that even existing quantum computers can use it.

 

Learning the "Quantum Advantage" of Physical Dynamics

 

Reference link:

https://www.science.org/doi/10.1126/science.abn7293
 
From theoretical research to practical application
 
 

The field of quantum technology has had an exciting year as 2024 approaches, preparing the opening chapter for breakthroughs. Looking back over the past few years, especially in the pivotal year of 2023, while we can't predict the future, the momentum in the quantum field has allowed us to chart the trends in the quantum landscape that are likely to shape this year.

 

Most notable are quantum-inspired developments in AI, especially those breakthroughs that make large language models smaller and more efficient. Quantum-inspired AI is expected to revolutionize the way we interact with generative AI such as ChatGPT, LLaMA, and others, enabling significant streamlining of model size without sacrificing accuracy.

 

Additionally, in 2024 we are also expected to see the rise of hybrid quantum machine learning techniques combining quantum and classical techniques, a fusion that runs on Noise-Intermediate Scale Quantum (NISQ) computers that can greatly expand the application areas of AI, and may even make it possible for models like ChatGPT to run on smartwatches.

 

In 2023, IBM achieved the milestone achievement of 1,121 superconducting quantum bits, and QuERA Computing developed 48 logic quantum bits using neutral atoms, signaling a major advance in hardware this year.

 

Google's Quantum Advantage experiment last year was also highly publicized, with its 70-qubit quantum computer successfully completing tasks that would have taken 47 years for the same task on a classical computer.

 

In addition to Google's quantum superiority, hardware development is focusing on three key areas - error mitigation, quantum error correction and scalability - to build deeper, more accurate quantum circuits and eventually support millions of error-correcting quantum bits.

 

2024 is expected to be a key year in the development of computer hardware beyond NISQ, and we expect to see the first clusters of quantum computers connected via quantum channels and working together. In terms of quantum error correction, quantum coding of more than 100 quantum bits is expected to be realized.

 

In short, 2024 will be the year that quantum technology goes beyond the hype and becomes truly integrated into everyday life. The synergy of inspired AI developments, hardware advances and venture capital investment is laying a solid foundation for this transformation.

 

In this regard, Jay Gambetta, vice president of IBM Quantum, said that quantum computers are on the verge of reaching a level of hardware that is sufficient to test more heuristic algorithms, which will set the stage for more use cases to emerge. Gambetta said, "We can finally start using hardware to discover algorithms. This opens up another new path for scientific discovery, and that's the most exciting part."

 
Reference Links:
[1]https://blog.research.google/2023/10/developing-industrial-use-cases-for.html
[2]https://spectrum.ieee.org/what-are-quantum-computers-used-for
[3]https://blog.research.google/2023/10/developing-industrial-use-cases-for.html
[4]https://www.eetimes.eu/2024-poised-to-be-a-pivotal-year-for-quantum-technologies/
 
2024-03-22